• Motivation and Reward system

  • Our behavior is motivated by rewards of different nature among which we frequently need to choose. We are addressing fundamental questions about the nature of motivated behavior to understand:
    - How the human brain processes rewards and punishments?

    - how computational factors such as reward probability and uncertainty are coded in the brain?
    - how different types of rewards engage specific brain systems?
    - how the brain assigns values to different options under consideration?
    - how gonadal steroid hormones modulate reward-related mechanisms and value-based decision making ?

    Selected publications

    - Dreher JC, Dunne S, Pazderska A, Frodl T, Nolan J.J, O’Doherty J.P, Testosterone Causes Both Prosocial and Antisocial Status-enhancing Behaviours in Human Males, PNAS USA, Oct 11, Vol 113, 41, 2016

    - E Metereau and JC Dreher. The medial orbitofrontal cortex encodes a general expected value signal during anticipation of both appetitive and aversive events, Cortex, Vol. 63, Pages 42–54,  2015

    - G Sescousse, Y Li and JC Dreher, A common currency for the computation of motivational values in the human striatum. Social Cognitive & Affective Neuroscience, 10(4):467-73, 2014

      - G Sescousse, X Caldù, B Segura, J-C Dreher, Common and specific neural structures processing primary and secondary rewards: a quantitative voxel-based meta-analysis, Neuroscience and Biobehavioral reviews, 37(4):681-96, 2013

    - J-C Dreher , P. Kohn, B. Kolachana, D.R. Weinberger, and K.F. Berman. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences USA, 106(2):617-22, 2009.

    - Copyright 2013 ISC-CNRS Created by Francesco De Fina