Motivation and Reward system
Our behavior is motivated by rewards of different nature among which we frequently need to choose. We are addressing fundamental questions about the nature of motivated behavior to understand:
- How the human brain processes rewards and punishments?
- how computational factors such as reward probability and uncertainty are coded in the brain?
- how different types of rewards engage specific brain systems?
- how the brain assigns values to different options under consideration?
- how gonadal steroid hormones modulate reward-related mechanisms and value-based decision making ?
- Dreher JC, Dunne S, Pazderska A, Frodl T, Nolan J.J, O’Doherty J.P, Testosterone Causes Both Prosocial and Antisocial Status-enhancing Behaviours in Human Males, PNAS USA, Oct 11, Vol 113, 41, 2016
- E Metereau and JC Dreher. The medial orbitofrontal cortex encodes a general expected value signal during anticipation of both appetitive and aversive events, Cortex, Vol. 63, Pages 42–54, 2015
- G Sescousse, Y Li and JC Dreher, A common currency for the computation of motivational values in the human striatum. Social Cognitive & Affective Neuroscience, 10(4):467-73, 2014
- G Sescousse, X Caldù, B Segura, J-C Dreher, Common and specific neural structures processing primary and secondary rewards: a quantitative voxel-based meta-analysis, Neuroscience and Biobehavioral reviews, 37(4):681-96, 2013
- J-C Dreher , P. Kohn, B. Kolachana, D.R. Weinberger, and K.F. Berman. Variation in dopamine genes influences responsivity of the human reward system. Proceedings of the National Academy of Sciences USA, 106(2):617-22, 2009.