Neurobiology of diseases
Understanding the neural bases of reward information and decision making processes are of crucial importance because of the fundamental role of rewards in behavioral processes such as motivation, learning and cognition and because of their theoretical and clinical implications for understanding dysfunctions of the dopaminergic reward system and a number of neuropathologies involving motivational and decision making disorders. We are studying the reward dopaminergic system and decision making mechanisms in healthy aging subjects and in a variety of neurological and psychiatric disorders in which motivation or decision making are dysfunctional, such as Parkinson’s disease, pathological gambling, eating disorders, schizophrenia and patients with focal prefrontal cortex lesions. One approach we are currently taking is to compare how different types of rewards are processed in brain disorders which are more specific of one reward domain (eg. food for anorexia, money in pathological gambling …).
- J Thomas, E Météreau, H Déchaud, M Pugeat, JC Dreher. Hormonal treatment increases the response of the reward system at the menopause transition: A counterbalanced randomized placebo-controlled fMRI study. Psychoneuroendocrinology, vol 50, Pages 167–18, 2014
- G Sescousse, G Barbalat, P Domenech B, J-C Dreher, Imbalance in the sensitivity to different types of rewards in pathological gambling, Brain, 136: 2527-38, 2013
- R Ligneul, G Sescousse, G Barbalat, P Domenech, J-C Dreher, Shifted risk preferences in pathological gambling, Psychological Medecine, vol 43, n°5, 1059-1068, 2013
- J-C Dreher, P. Koch, P. Kohn, J. Apud, D. Weinberger and K.F. Berman. Common and differential pathophysiological features accompany comparable cognitive impairments in medication-free patients with schizophrenia and in healthy aging subjects, Biological Psychiatry, 1(10):890-7, 2012
- J-C Dreher , A. Meyer-Lindenberg, P. Kohn and K. F. Berman. Age-related changes in midbrain dopaminergic regulation of the human reward system. Proceedings of the National Academy of Sciences USA, 105(39):15106-11, 2008